How Long Does it Take for Testosterone Injection to Work?

Countless studies in the US and internationally have documented the positive benefits of testosterone injections as a treatment for male hypogonadism. Although testosterone is traditionally associated with male sexual characteristics, sex drive, and physical performance.

What to expect from testosterone injections?

Because T levels in early adulthood are rarely known, the amount of testosterone shots needed to correct symptoms and the onset of action is highly variable. When testosterone is lower than what the body needs, the hormone estrogen becomes more dominant. That results in a significant loss of muscle tone and increased fat deposits.

When T levels in men drop, many men often feel as if they’ve lost their manhood and women lose their interest in sex. In men, this is a direct result of increased estrogen relative to testosterone production in the body.

In women, who also lose estrogen in menopause, the overall effect of testosterone loss is a hormonal imbalance

Understanding how men and women benefit from the therapy, it is important to know that the benefits are cumulative. As the TRT progresses, the beneficial effects will continue to improve. Keep in mind that each person has their own unique experience.

As with any medical treatment, baseline blood tests will be performed done before beginning TRT. The tests are generally done in the morning on two separate days.

The blood levels of testosterone will be measured at various intervals to determine the optimal response while minimizing any adverse reactions. After that, you can calculate your free and bioavailable testosterone levels for an accurate diagnosis.

What to expect from testosterone injections?

The benefits of testosterone treatment include the following

  • More energy
  • Increased metabolism
  • Better sex drive and longer-lasting erections
  • More intense orgasms
  • Reduced body fat
  • Better sleep quality
  • Enhanced muscle tone and strength
  • Reduces the risk of depression and anxiety
  • Improved energy

Testosterone treatment can help achieve muscular definition and tone, aid in fat metabolism, and increase libido. Essentially, the hormone can assist men in an effort to become more active and live a more healthy life.

Testosterone injections take a few weeks to kick in before feeling the beneficial effects

 What is the best time to take injections?

It doesn’t matter what time of day you take an injection because it is given so infrequently and lasts a long time. Creams and pills need daily dosing and are usually applied or taken at night.

Commonly used dosages for testosterone shots

Testosterone Undecanoate is used at a dose of 750 mg and repeated in four months, then again in 10 weeks at the same doses.

This form of testosterone can be given another route besides IM. It is in the category of androgens. IM formulations take an effect in about 7 days (median; range: 4 to 42 days) and can last 10 weeks. Your doctor can give you injections at their office, or you can give yourself a testosterone injection at home, as millions of users around the world do.

Most common testosterone shot dosage

The most common side effect is contact dermatitis at the injection site. The body metabolizes it by the liver and excretes it in the urine. It can be used for delayed puberty, metastatic breast cancer, and low T levels.

Testosterone Enanthate and Cypionate is injected starting at 50 mg and can be increased up to 400 mg every 2 to 4 weeks.

Enanthate is the European version while Cypionate is manufactured in the U.S.

Testosterone Cypionate and Enanthate have the same purpose, effects and functions. Cypionate may last longer than Enanthate. Cypionate is called Depo-Testosterone.

Both are androgens and anabolic steroids and are used for people with testosterone deficiency, delayed puberty, or low T production, known as hypogonadism.

TRT timeline outlined by 6-month span

Before getting a testosterone prescription for injections, a person must first visit a local lab for the required blood tests and undergo a physical examination that can be sent to our clinic.

Once the blood tests and physical exam results are available, the doctor will compare this information with the medical history of the client to determine the significance of low T. This will establish the diagnosis of low T, allowing a dosage plan to be implemented for TRT.

Testosterone can help achieve muscular definition and tone, aid in fat metabolism, and increase libido. Assisting men and women in their effort to become more active and live a more healthful life. 

The actual testosterone therapy results timeline experienced by each person will be variable, and the onset of symptom-relief is highly individualized. Although there are some general expectations that can be evaluated to show if a person is benefiting from the therapy.

Here are some general expectations that depend on the initial testosterone deficit and the length of time it has been present.

First month

  • Increased sex drive and satisfaction
  • Improved energy and quality of life
  • Insulin sensitivity may begin to improve and keep glucose levels more steady
  • Greater energy
  • Possibly a decrease in total cholesterol

 Second month

  • Improved mood
  • Lowering of body inflammation markers
  • In women, a reduction in hot flashes

Third month

  • Reduced anxiety and agitation
  • Increased erections and orgasms
  • Decreased total cholesterol and triglycerides
  • Increased HDL (good) cholesterol may begin
  • Improvements in glycemic control- glucose levels
  • Increased production of red blood cells
  • Possible lowered diastolic blood pressure (maximum effects noted at 12-month mark)
  • Better exercise capacity

Fourth month

The results of taking testosterone may stabilize at any point between six and twelve months after starting TRT. And continue to benefit people over the coming years.

  • Noticeable improvements in fat reduction
  • Increased lean muscle mass and strength

Fifth month

During this month, there will continue to be an overall benefit and stabilization of many health parameters. Monitoring for side effects may result in an adjustment in the dose.

Sixth month

Both men and women experience thinning of the bones but women at a faster pace after menopause for women. Both low estrogen and low testosterone contribute to bone loss.

  • Thickening of hair may occur
  • Better cognition

How long does testosterone stay in your system?

Testosterone stays in your system for 2-4 weeks (10 weeks in the case of Undecanoate) and gradually gets metabolized and excreted from your system. However, muscle mass and hair growth take longer to regress after stopping injections.

What will happen when you stop taking testosterone?

The effects of testosterone shots will wear off gradually over time. It depends on the previous dose, the duration of the therapy, and the underlying reason for prescribing it. That also means that the symptoms of the deficiency will return slowly.

What are the side effects of injections?

Some of the side effects of testosterone include oily skin, acne, hair growth in unwanted places, nausea, water retention, headaches, the risk for erythrocytosis and high hematocrit, elevated cholesterol. Side effects may signify a need to change the dosage.

In order to achieve favorable results with TRT with the least chance of adverse reactions. It is necessary to work with a medical expert in the hormone replacement field.

More Common Side effects:

  • Gum or mouth irritation

Less common side effects:

  • Bad, unusual, or unpleasant (after) taste
  • Bleeding gums
  • Change in taste
  • Cough
  • Crying
  • Depersonalization
  • Dry mouth
  • Dizziness
  • Dysphoria
  • Fear or nervousness
  • Hoarseness
  • Irritability
  • loss of appetite
  • Painful or difficult urination

Do other forms of testosterone work?

Testosterone treatment in the form of creams, gels, and pills work, but the effects are not as dramatic and take longer to kick in. The creams and gels penetrate the skin and fat slowly and must be taken up by the bloodstream to have their effect. The other disadvantage is that topicals can be transmitted to other people via skin-to-skin contact.

No two individuals will ever experience or process hormones, drugs, feelings, or the aging process in the same manner. That’s why testosterone treatment is individualized based on underlying signs and symptoms.

The response to therapy is monitored to address personal needs and minimize side effects. Injections are prescription medications and should only be used under the supervision of a qualified health professional. Report any unusual symptoms immediately.

Get a free consultation with our medical expert for any questions about hormone replacement therapy